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DNA ligase repairing chromosomal damage
Replication and repair
A broad search by molecular biologists for DNA ligase, an enzyme that connects pieces of DNA, leads to independent reports of the isolation and characterization of the peptide from five different laboratories – those directed by Martin Gellert of the National Institutes of Health, Jerard Hurwitz of the Albert Einstein College of Medicine, I.R. Lehman of Stanford, and Charles R. Richardson of the Harvard Medical School. DNA ligase repairs the splices and lesions that occur naturally in DNA molecules during replication. It is among the last few additions to the laboratory toolbox that enables molecular biologists to develop recombinant DNA.